Glucose biosensors based on a gold nanodendrite modified screen-printed electrode

Area of Science:

• Electrochemistry
• Nanomaterials Science
• Biosensor Technology

Background:

• Screen-printed electrodes (SPEs) are widely used in electrochemical sensing.
• Enhancing the surface area of SPEs is crucial for improving biosensor sensitivity.
• Gold nanostructures offer unique electrochemical properties for biosensor applications.

Purpose of the Study:

• To develop a highly sensitive enzymatic glucose biosensor.
• To utilize three-dimensional gold nanodendrites (GNDs) for electrode modification.
• To improve glucose detection performance using modified screen-printed electrodes.

Main Methods:

• Electrochemical synthesis of three-dimensional gold nanodendrites (GNDs) on a screen-printed electrode.
• Modification of the working electrode of a commercial screen-printed electrode.
• Enzymatic detection of glucose using glucose oxidase.

Main Results:

• The fabricated biosensor exhibited a sensitivity of 46.76 μA mM⁻¹ cm⁻².
• A wide linear detection range for glucose was achieved (28 μM–8.4 mM).
• A low detection limit of 7 μM and a fast response time of approximately 3 seconds were recorded.

Conclusions:

• The three-dimensional gold nanodendrite modified electrode significantly enhances glucose detection sensitivity.
• The developed enzymatic glucose biosensor offers excellent performance characteristics for glucose monitoring.
• The use of commercial screen-printed electrodes reduces the required amount of glucose oxidase.