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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...

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Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Alarmin-induced cell migration.

De Yang1, Feng Wei, Poonam Tewary

  • 1Basic Research Program, Scientific Application and International Corporation-Frederick, Inc, Frederick, MD, USA. yangd@mail.nih.gov

European Journal of Immunology
|April 27, 2013
PubMed
Summary
This summary is machine-generated.

Alarmins, or damage-associated molecular patterns, guide immune cell movement. Understanding alarmin-induced cell migration is crucial for innate and adaptive immunity and diverse biological processes.

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Related Experiment Videos

Last Updated: May 11, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
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Published on: May 13, 2012

In vitro Cell Migration and Invasion Assays
09:55

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Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos
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Analyzing In Vivo Cell Migration using Cell Transplantations and Time-lapse Imaging in Zebrafish Embryos

Published on: April 29, 2016

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Alarmins are endogenous damage-associated molecular patterns that initiate immune responses.
  • Leukocyte trafficking is essential for proper immune system function.
  • Chemotactic factors, including alarmins, direct cell migration.

Purpose of the Study:

  • To provide an overview of alarmin-induced cell migration.
  • To explore the mechanisms by which alarmins influence leukocyte and nonleukocyte movement.
  • To highlight the role of alarmins in immune cell recruitment and trafficking.

Main Methods:

  • This viewpoint synthesizes existing research on alarmins and cell migration.
  • It discusses the direct and indirect mechanisms of alarmin-induced migration.
  • Receptor-ligand interactions and intracellular signaling pathways are examined.

Main Results:

  • Alarmins directly induce migration by activating specific receptors, such as Gαi protein-coupled receptors and the receptor for advanced glycation end products.
  • Alarmins indirectly promote migration by stimulating chemokine production in leukocytes.
  • The intracellular signaling events underlying direct alarmin chemotaxis are not fully understood.

Conclusions:

  • Alarmins are key regulators of leukocyte and nonleukocyte migration.
  • They play a significant role in both innate and adaptive immunity.
  • Alarmins' involvement in diverse biological processes warrants further investigation.