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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
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Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: May 11, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

[Merkel cell carcinoma: (r)evolution].

Laurence Feldmeyer1, Olivier Gaide

  • 1Service de dermatologie et vénéréologie, Hôpital de Beaumont, CHUV, 1011 Lausanne. laurence.feldmeyer@chuv.ch

Revue Medicale Suisse
|April 30, 2013
PubMed
Summary

Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer, particularly in the elderly. Recent scientific advances are revolutionizing its understanding, diagnosis, and treatment.

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Research

Context:

  • Merkel cell carcinoma (MCC) is an aggressive skin cancer, a leading cause of skin cancer mortality.
  • The incidence of MCC is rising, particularly in the elderly population.
  • Recent research highlights significant advancements in understanding MCC.

Purpose:

  • To review recent breakthroughs in Merkel cell carcinoma research.
  • To compare MCC with more common skin cancers like melanoma and squamous cell carcinoma.
  • To provide an overview of the evolving landscape of MCC diagnosis and therapy.

Summary:

  • Significant progress has been made in understanding the biology and pathogenesis of MCC.
  • Novel diagnostic tools and therapeutic strategies are emerging for MCC.

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  • Comparative analyses with melanoma and squamous cell carcinoma offer insights into MCC's unique characteristics.

    • Impact:

    • These advances promise to improve the clinical management and patient outcomes for Merkel cell carcinoma.
    • The study underscores the rapid growth of knowledge in MCC, impacting clinical practice.
    • Enhanced understanding facilitates the development of targeted therapies for this rare but deadly skin cancer.