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Updated: May 11, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
Viral infectivity factor: a novel therapeutic strategy to block HIV-1 replication
1Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, College of Chemistry and Life Science, Huanggang Normal University, No. 146, Xingang 2 Road, Huanggang 438000, Hubei, P.R. China. guliang_yang@163.com
Abstract:
The HIV-1 viral infectivity factor (Vif), one of the six accessory proteins, is essential for viral replication and pathogenesis. Its main function is to form Vif-Cullin5-ElonginBC complex and then is able to ubiquitinate and degrade the human anti-viral factor APOBEC3G, which markedly enhances the virus infectivity. Delete Vif leads to the loss of the infectivity of HIV-1; therefore, Vif is a potentially new attractive target for therapeutic intervention in AIDS. This review describes the structure, function and especially inhibitors of HIV-1 Vif.
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