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Updated: May 11, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Basal cell carcinoma arising from xeroderma pigmentosum: a case report and an immunohistochemical study
Sadanori Furudate1, Taku Fujimura, Gen-Ichi Tojo
1Department of Dermatology, Yamato Takada Municipal Hospital, Nara.
Abstract:
We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages, together with Foxp3(+) regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was also detected in the CD163(+) M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.
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