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Published on: August 7, 2014

Prekallikrein deficiency.

M Thomas Quail1

  • 1Department of Public Health, Bureau of Environmental Health, Commonwealth of Massachusetts, Boston, MA 02108, USA. tom.quail@state.ma.us

Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses
|May 1, 2013
PubMed
Summary
This summary is machine-generated.

Prekallikrein deficiency, a rare inherited bleeding disorder, causes a prolonged activated partial thromboplastin time (PTT) with a normal prothrombin time (PT). This review aids nurses in identifying causes of abnormal PTT results.

Keywords:
Fletcher factor deficiencycoagulationhemostasisnursingprekallikrein deficiency

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Area of Science:

  • Hematology
  • Coagulation Disorders
  • Clinical Nursing

Background:

  • Abnormal laboratory assays necessitate further investigation for optimal patient care.
  • A prolonged activated partial thromboplastin time (PTT) with a normal prothrombin time (PT) may indicate laboratory error or underlying bleeding disorders.
  • Prekallikrein deficiency, a rare autosomal recessive coagulation disorder, is characterized by a prolonged PTT and normal PT.

Purpose of the Study:

  • To provide nurses with a foundational understanding of hemostasis.
  • To identify six potential causes for a prolonged PTT with a normal or slightly prolonged PT.
  • To present two novel cases of recently diagnosed adult prekallikrein deficiency.

Main Methods:

  • Literature review on hemostasis and coagulation disorders.
  • Analysis of diagnostic criteria for prolonged PTT and normal PT.
  • Case study presentation of two adult patients with prekallikrein deficiency.

Main Results:

  • Prekallikrein deficiency, historically known as Fletcher factor deficiency, presents with a prolonged PTT and normal PT.
  • Six distinct causes for this laboratory finding were identified.
  • Two previously unreported adult cases of prekallikrein deficiency were diagnosed.

Conclusions:

  • Nurses play a crucial role in recognizing and investigating abnormal coagulation assays.
  • Understanding rare bleeding disorders like prekallikrein deficiency is essential for accurate diagnosis and patient management.
  • This review equips nurses with knowledge to differentiate prekallikrein deficiency from other causes of prolonged PTT.