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Updated: May 11, 2026
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Central corneal regularization--optimization of uncorrected visual acuity in keratoconus patients
C Kaufmann1, F Bochmann, P Baenninger
1Dept. of Ophthalmology, Cantonal Hospital Lucerne, Lucerne, Switzerland. claude.kaufmann@luks.ch
Klinische Monatsblatter Fur Augenheilkunde
|May 1, 2013
Summary
This study shows that combining corneal cross-linking with central corneal regularization can significantly improve uncorrected visual acuity in keratoconus patients. The treatment offers a promising approach for enhancing vision in ectatic corneas.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Vision Science
Background:
- Keratoconus treatment is evolving with combined excimer laser correction and corneal cross-linking.
- Central corneal regularization uses topography-guided ablation for ectatic corneas.
- This aims to correct irregular astigmatism and improve corneal surface regularity.
Purpose of the Study:
- To evaluate the efficacy of combined corneal cross-linking and central corneal regularization.
- To assess the impact on uncorrected visual acuity in keratoconus patients.
Main Methods:
- Prospective single-center study.
- 10 keratoconus patients received combined corneal cross-linking and central corneal regularization using an iRES-Laser.
- Uncorrected visual acuity was measured at 1 and 3 months postoperatively.
Main Results:
- Mean preoperative uncorrected visual acuity was 0.15.
- Mean postoperative uncorrected visual acuity improved to 0.28 at 1 month and 0.24 at 3 months.
- The results indicate a positive trend in visual acuity improvement.
Conclusions:
- Combined corneal cross-linking and central corneal regularization shows potential for significant visual acuity improvement.
- This combined treatment is a promising option for keratoconus management.
- Further research may validate these findings in larger cohorts.
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