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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
Clinical impact of 8 prospective, randomized, multicenter glaucoma trials
Joseph F Panarelli1, Michael R Banitt, Paul A Sidoti
1*Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL †Department of Ophthalmology, New York Eye and Ear Infirmary, New York ‡New York Medical College, Valhalla, NY §Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, NC ∥Department of Ophthalmology, Stanford University, Palo Alto, CA.
Journal of Glaucoma
|May 2, 2013
Summary
Randomized clinical trials (RCTs) significantly impact glaucoma practice, with varying effects observed across studies. The Ocular Hypertension Treatment Study (OHTS) showed the greatest influence on clinical decisions.
Area of Science:
- Ophthalmology
- Clinical Trials
- Glaucoma Management
Background:
- Glaucoma management is guided by evidence from multicenter randomized clinical trials (RCTs).
- Understanding the clinical impact of these RCTs is crucial for evidence-based practice.
Purpose of the Study:
- To assess the impact of eight major multicenter randomized clinical trials (RCTs) on the clinical practice of glaucoma specialists.
- To identify variations in the perceived influence of these RCTs among practitioners.
Main Methods:
- An electronic survey was administered to members of the American Glaucoma Society (AGS).
- Participants rated the impact of eight specific RCTs (AGIS, CIGTS, CNTG, EGPS, EMGT, GLT, OHTS, TVT) on their practice using a 5-point Likert scale.
- Demographic data on practice setting and experience were collected.
Main Results:
- A response rate of 23.0% (206/894 AGS members) was achieved.
- The Ocular Hypertension Treatment Study (OHTS) received the highest mean impact score (4.47), followed by the Collaborative Normal Tension Glaucoma (CNTG) Study (4.13).
- The European Glaucoma Prevention Study (EGPS) had the lowest reported impact (2.69).
Conclusions:
- Significant differences exist in the clinical impact of various glaucoma RCTs.
- Factors such as study design, timing, conduct, and interpretation likely influence the perceived impact of each trial on clinical practice.
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