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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Systemic arterial stiffness in patients with pseudoexfoliation glaucoma
Kemal Türkyilmaz1, Veysi Oner, Yüksel Ciçek
1Departments of *Ophthalmology †Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize ‡Maya Eye Clinic, Kayseri, Turkey.
Journal of Glaucoma
|May 2, 2013
Summary
Patients with pseudoexfoliation (PEX) glaucoma exhibit higher carotid-femoral pulse wave velocity (CF-PWV) compared to healthy individuals. Increased CF-PWV may serve as a risk factor for developing PEX glaucoma.
Area of Science:
- Ophthalmology
- Cardiovascular Physiology
Background:
- Pseudoexfoliation (PEX) glaucoma is an ocular condition associated with systemic vascular abnormalities.
- Arterial stiffness, measured by carotid-femoral pulse wave velocity (CF-PWV), is an indicator of cardiovascular health.
Purpose of the Study:
- To investigate carotid-femoral pulse wave velocity (CF-PWV) in patients diagnosed with pseudoexfoliation (PEX) glaucoma.
- To compare CF-PWV values between PEX glaucoma patients and a healthy control group.
Main Methods:
- A cohort of 25 patients with PEX glaucoma and 25 age- and sex-matched healthy controls were recruited.
- Carotid-femoral pulse wave velocity (CF-PWV) was measured noninvasively using pulse transit time and distance between recording sites.
Main Results:
- The study included patients with a mean age of approximately 64 years.
- Carotid-femoral pulse wave velocity (CF-PWV) was found to be significantly elevated in the pseudoexfoliation glaucoma group compared to the control group (P<0.001).
Conclusions:
- An association exists between pseudoexfoliation glaucoma (PEXG) and increased carotid-femoral pulse wave velocity (CF-PWV).
- Elevated CF-PWV may represent a potential risk factor for the development or progression of PEX glaucoma.
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