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Updated: May 11, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Wavelength-multiplexing phase-sensitive surface plasmon imaging sensor.

Yonghong Shao¹, Yan Li, Dayong Gu

¹College of Optoelectronics Engineering, Key Laboratory of Optoelectronic Devices and Systems, Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, China. shaoyh@szu.edu.cn

|May 2, 2013

Summary

This summary is machine-generated.

This study introduces a new wavelength-multiplexing phase-sensitive surface plasmon resonance (SPR) imaging sensor. This advanced sensor offers a wide dynamic range and microarray capabilities for enhanced biosensing applications.

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Last Updated: May 11, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

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Published on: March 17, 2023

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Area of Science:

Nanotechnology
Optical Sensors
Biomedical Engineering

Background:

Surface Plasmon Resonance (SPR) imaging is a label-free technique for detecting biomolecular interactions.
Existing SPR imaging sensors often face limitations in dynamic range and sensitivity.
Phase-sensitive detection offers potential advantages over intensity-based methods in SPR sensing.

Purpose of the Study:

To develop and characterize a novel wavelength-multiplexing phase-sensitive SPR imaging sensor.
To achieve a wide dynamic detection range and microarray capability.
To improve the sensitivity and robustness of SPR imaging for various applications.

Main Methods:

Utilized wavelength-multiplexing with a liquid crystal tunable filter to select SPR excitation wavelengths.
Implemented phase detection via self-interference of s- and p-polarized light.
Integrated microarray capability for parallel sensing.

Main Results:

Demonstrated a high-resolution detection limit of 2.7×10⁻⁷ Refractive Index Units (RIU).
Achieved a wide dynamic detection range of 0.0138 RIU.
The phase-sensitive approach showed less stringent requirements for signal-to-noise ratio.

Conclusions:

The developed SPR imaging sensor offers a significant advancement in sensitivity and dynamic range.
Wavelength-multiplexing and phase-sensitive detection enable robust and versatile biosensing.
This technology holds promise for high-throughput, sensitive biomolecular detection in various fields.