Related Experiment Video
Updated: May 11, 2026
04:48
Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
Published on: November 28, 2018
Aging does not affect radial viscoelastic behavior of the left ventricle
Jan O Mangual1, Daniela Föll, Bernd Jung
1University of Florence, Florence, Italy.
Cardiology
|May 3, 2013
Summary
Aging does not significantly alter left ventricular (LV) radial viscoelasticity, despite changes in myocardial velocity. This cardiac tissue property remains consistent across different age groups.
Area of Science:
- Cardiovascular research
- Biomedical engineering
- Medical imaging analysis
Background:
- Aging impacts regional myocardial motion, particularly velocities.
- The effect of aging on cardiac viscoelasticity, a time-dependent strain property, remains unclear.
- Previous research highlights age-related changes in myocardial function.
Purpose of the Study:
- To investigate the influence of aging on the radial viscoelastic behavior of the left ventricle (LV).
- To utilize myocardial tissue phase mapping (TPM) of cine phase-contrast MRI for assessing LV viscoelasticity.
- To compare viscoelasticity parameters across different age groups.
Main Methods:
- Myocardial velocity and displacement mapping of the LV were performed using TPM.
- 39 healthy subjects were divided into three age groups for analysis.
- Viscoelasticity parameters were calculated for each LV segment and compared between groups.
Main Results:
- Myocardial elasticity ranged from approximately 20 to -20 dyne/cm² during the cardiac cycle.
- The myocardial viscous-damping component ranged from -1 to 1 dyne × s/cm².
- No statistically significant differences in viscoelasticity components were found among the age groups (p > 0.05).
Conclusions:
- Radial viscoelastic behavior of the LV shows similar patterns and magnitudes across different age groups.
- Aging does not lead to statistically significant differences in LV radial viscoelasticity.
- These findings contrast with known age-related changes in regional myocardial velocities.
More Related Videos
Related Concept Videos
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:15Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
01:29Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
01:20Normal Strain under Axial Loading
Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...