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Adherence to targeted oral anticancer medications.
Daniel M Geynisman1, Karen E Wickersham
1Section of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, 5841 S. Maryland Ave., Chicago, Illinois 60637, USA.
Discovery Medicine
|May 3, 2013
Summary
Adherence to oral anticancer medications (OAMs) is crucial for cancer treatment effectiveness. This review examines challenges and interventions for OAM adherence in various cancers to improve patient outcomes.
Area of Science:
- Oncology
- Pharmacology
- Patient Adherence Research
Background:
- Oral anticancer medications (OAMs) represent a significant portion of cancer drug development and approvals.
- The shift towards self-administered OAMs necessitates a focus on patient adherence.
- Over 50 OAMs are FDA-approved, transforming cancer treatment paradigms.
Purpose of the Study:
- To review adherence challenges associated with molecularly targeted OAMs in specific cancers.
- To identify barriers to OAM adherence.
- To evaluate interventions aimed at improving OAM adherence.
Main Methods:
- Literature review of studies on OAM adherence in breast cancer, CML, GIST, NSCLC, and RCC.
- Analysis of reported barriers to adherence.
- Examination of interventions designed to enhance adherence.
Main Results:
- Adherence to OAMs presents unique challenges in chronic cancer therapy.
- Identified barriers include [specific barriers to be detailed in full study].
- Various interventions have been tested to improve adherence, with [summary of effectiveness to be detailed in full study].
Conclusions:
- Improving adherence to oral anticancer medications is essential for optimizing targeted cancer therapy.
- Further research is needed to define and enhance OAM adherence strategies.
- Understanding and addressing adherence barriers can improve patient outcomes in oncology.
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