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Related Experiment Video

Updated: May 11, 2026

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

Upper Egypt experience in bladder preservation using concurrent chemoradiotherapy.

Ahmed M Maklad¹, Elsayed M Ali, Ashraf Elyamany

¹Clinical Oncology Department, Sohag University, Sohag, Egypt. ahmaklad2003@yahoo.com.

International Archives of Medicine

|May 7, 2013

Summary

Bladder preservation for muscle invasive bladder cancer using radiochemotherapy shows promising results. Tumor size and completeness of transurethral resection are key factors for successful bladder preservation and improved survival outcomes.

Related Experiment Videos

Last Updated: May 11, 2026

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

Area of Science:

Oncology
Urology

Background:

Muscle invasive bladder cancer (MIBC) necessitates aggressive treatment, often involving radical cystectomy.
Bladder preservation strategies aim to maintain organ function while effectively treating MIBC.

Purpose of the Study:

To report on bladder preservation experiences in Upper Egypt using distinct treatment protocols at Assiut and Sohag Universities.
To evaluate the efficacy and prognostic factors associated with bladder preservation in MIBC.

Main Methods:

Sohag study: Transurethral resection (TUR) followed by radiochemotherapy (5-fluorouracil and cisplatin) for operable MIBC.
Assiut study: Maximum safe resection followed by chemoradiotherapy (60 Gy radiotherapy, cisplatin, and gemcitabine).

Main Results:

In Assiut, 90% of patients achieved disease-free status post-cystoscopic reevaluation. However, local recurrence was observed in 74% of complete responders within 18 months.
Sohag study reported recurrence-free survival of 84% at 17 months and 70% at 30 months. Overall survival was 95% at 17 months and 84% at 30 months.
Assiut study showed disease-free survival of 66.7% and overall survival of 76.7%.

Conclusions:

Significant prognostic factors for overall survival in Assiut included performance status, tumor size, and residual tumor.
Tumor size and residual tumor were significant for disease-free survival in Assiut.
Completeness of TUR and early tumor stage were identified as crucial for treatment response, consistent with findings from both studies.