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Related Experiment Video

Updated: May 11, 2026

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap

Published on: January 16, 2014

Amygdala functional connectivity is reduced after the cold pressor task.

David Clewett¹, Andrej Schoeke, Mara Mather

¹University of Southern California, Los Angeles, CA, USA, clewett@usc.edu.

Cognitive, Affective & Behavioral Neuroscience

|May 7, 2013

Summary

This summary is machine-generated.

Painful stressors alter brain connectivity. Acute pain from a cold pressor task reduced functional connectivity between the amygdala and prefrontal regions, independent of cortisol levels.

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Area of Science:

Neuroscience
Psychophysiology
Pain Research

Background:

The amygdala is a key node linking pain and stress pathways.
Psychological stress impacts amygdala activity, but effects of painful stressors on functional connectivity are less understood.

Purpose of the Study:

To investigate how painful stressors affect resting-state amygdala functional connectivity.
To examine differences in amygdala connectivity following a cold pressor task versus a control condition.

Main Methods:

Utilized pulsed arterial spin labeling (PASL) to assess resting-state functional connectivity in healthy adult males.
Compared connectivity patterns 15-30 minutes after a cold pressor task versus a control task on separate days.
Measured functional connectivity during a 6-minute eyes-closed rest period.

Main Results:

The cold pressor task reduced functional connectivity between the amygdala and orbitofrontal cortex (OFC) and ventromedial prefrontal cortex, irrespective of cortisol.
Increased inverse connectivity was observed between the left amygdala and dorsal anterior cingulate cortex (ACC).
The degree of amygdala decoupling with the lateral OFC correlated with self-reported pain intensity during the stressor.

Conclusions:

The cold pressor task alters amygdala interactions with prefrontal and ACC regions within 15-30 minutes post-stressor.
These functional connectivity changes are linked to pain perception, not cortisol feedback.