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Magnetite nanoparticles-chitosan composite containing carbon paste electrode for glucose biosensor application.

A L Kavitha1, H Gurumallesh Prabu, S Ananda Babu

  • 1Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi 630003, India.

Journal of Nanoscience and Nanotechnology
|May 8, 2013
PubMed
Summary

Researchers developed a novel glucose biosensor using a magnetite-chitosan composite carbon paste electrode. This reusable biosensor offers sensitive glucose detection with enhanced stability and reduced interference.

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Area of Science:

  • Electrochemistry
  • Biomaterials Science
  • Biosensor Technology

Background:

  • Development of sensitive and stable biosensors is crucial for accurate glucose monitoring.
  • Carbon paste electrodes modified with nanomaterials offer improved electrochemical performance.
  • Chitosan and magnetite composites show promise for enzyme immobilization and biosensor fabrication.

Purpose of the Study:

  • To develop a reusable magnetite-chitosan composite carbon paste electrode for biosensor applications.
  • To immobilize glucose oxidase (GOx) onto the composite electrode for sensitive glucose detection.
  • To characterize the electrochemical properties and stability of the developed biosensor.

Main Methods:

  • Fabrication of a carbon paste electrode modified with a magnetite-chitosan nanocomposite.
  • Immobilization of glucose oxidase (GOx) enzyme onto the modified electrode.
  • Electrochemical characterization of the biosensor using techniques to study surface parameters (surface coverage, diffusion coefficient, rate constant).

Main Results:

  • The developed GOx-magnetite-chitosan nanocomposite carbon paste electrode demonstrated sensitive glucose detection.
  • The immobilized enzyme retained bioactivity and exhibited stable, reversible electron transfer.
  • The biosensor showed excellent stability, with a shelf life of approximately 12 weeks under refrigeration.
  • The modified electrode effectively minimized interference during glucose detection.

Conclusions:

  • The magnetite-chitosan composite carbon paste electrode is a promising platform for developing reusable and stable glucose biosensors.
  • The enhanced performance is attributed to the synergistic properties of chitosan, magnetite, and GOx, promoting enzyme absorption and electron transfer.
  • This novel fabrication represents a significant advancement in carbon paste bioelectrode development for glucose sensing.