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Choroidal vessel diameter in central serous chorioretinopathy
Lihong Yang1, Jost B Jonas, Wenbin Wei
1Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Acta Ophthalmologica
|May 8, 2013
Summary
Central serous choroidopathy (CSC) involves enlarged choroidal vessels, even in unaffected eyes, suggesting a systemic component. Macular swelling in CSC is linked to significant vascular engorgement in the choroid.
Area of Science:
- Ophthalmology
- Medical Imaging
- Vascular Biology
Background:
- Central serous choroidopathy (CSC) is a condition characterized by fluid accumulation under the macula.
- The role of choroidal vascular changes in CSC pathogenesis is not fully understood.
Purpose of the Study:
- To measure the hyporeflective lumen, indicative of choroidal vessels, in patients with CSC.
- To compare these measurements with a control group and contralateral unaffected eyes.
Main Methods:
- A prospective comparative observational study involving 15 CSC patients and 15 controls.
- Enhanced depth imaging optical coherence tomography (OCT) was used to measure subfoveal choroidal thickness (SFCT) and the largest hyporeflective lumen diameter.
Main Results:
- Affected CSC eyes had significantly larger SFCT (455 ± 73 μm) than unaffected eyes (387 ± 94 μm) and controls (289 ± 71 μm).
- The largest hyporeflective lumen diameter was significantly larger in unaffected CSC eyes (251 ± 98 μm) compared to controls (140 ± 40 μm).
- Vessel diameter strongly correlated with total choroidal thickness (p < 0.001).
Conclusions:
- Patients with CSC exhibit enlarged choroidal vessels in affected eyes compared to unaffected and control eyes.
- Macular swelling in CSC is associated with significant choroidal vascular engorgement.
- The involvement of clinically unaffected eyes suggests a potential systemic component in CSC.
