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Understanding acid lability of cysteine protecting groups

Iván Ramos-Tomillero1, Lorena Mendive-Tapia, Miriam Góngora-Benítez

  • 1Institute for Research in Biomedicine-IRB Barcelona, Baldiri Reixac 10, 08028-Barcelona, Spain.

Molecules (Basel, Switzerland)
|May 8, 2013
PubMed
Summary

Understanding acid-labile protecting groups for cysteine (Cys) is key for peptide synthesis. Carbocation stability during acid treatment directly impacts Cys protecting group removal, guiding the development of new peptide synthesis strategies.

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