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Related Concept Videos

Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Published on: September 22, 2019

Probiotics and IBD.

Elisabeth De Greef1, Yvan Vandenplas, Bruno Hauser

  • 1Pediatric Gastroenterology, Hepatology and Nutrition, UZ Brussel, Belgium.

Acta Gastro-Enterologica Belgica
|May 9, 2013
PubMed
Summary
This summary is machine-generated.

Probiotics and prebiotics show promise for managing inflammatory bowel disease (IBD), particularly ulcerative colitis, though results for Crohn's disease are less encouraging. This review examines their use in adults and children.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • The pathophysiology of inflammatory bowel disease (IBD) remains incompletely understood.
  • Pediatric IBD often presents with more severe and extensive disease.
  • Aberrant immune responses to intestinal microbiota suggest an 'ecological' approach may be beneficial.

Purpose of the Study:

  • To review the use of probiotics and prebiotics in managing IBD.
  • To assess the efficacy of these interventions in adults and children.
  • To provide a perspective on pediatric-specific issues related to IBD management.

Main Methods:

  • Review of existing studies on probiotics and prebiotics in IBD.
  • Analysis of data concerning adult and pediatric patient populations.
  • Evaluation of treatment outcomes for Crohn's disease and ulcerative colitis.

Main Results:

  • Probiotics and prebiotics have shown disappointing results for Crohn's disease.
  • Encouraging outcomes have been observed for ulcerative colitis.
  • The review provides an overview of studies in both adult and pediatric populations.

Conclusions:

  • Probiotics and prebiotics represent a potential 'ecological' strategy for IBD management.
  • Their efficacy varies between Crohn's disease and ulcerative colitis.
  • Further research, particularly focusing on pediatric IBD, is warranted.