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Positive correlation between variants of lipid metabolism‑related genes and coronary heart disease

Li-Na Zhang1, Pan-Pan Liu, Jianqing Zhou

  • 1School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, PR China. zhanglina@nbu.edu.cn

Molecular Medicine Reports
|May 9, 2013
PubMed

Insights

This study investigated gene variants and coronary heart disease (CHD) in the Han Chinese population. The LIPA gene variant rs2246942-GG increased CHD risk, while the LPA gene variant rs7767084-CC showed a protective effect in females.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Population Studies

Background:

  • Four gene variants (rs562338, rs503662 of APOB; rs7767084 of LPA; rs2246942 of LIPA) are linked to coronary heart disease (CHD).
  • Understanding the association of these variants with CHD in the Han Chinese population is crucial for risk assessment.

Purpose of the Study:

  • To assess the association of four specific gene variants with CHD in the Han Chinese population.
  • To determine the contribution of these gene variants to CHD risk and protective effects.

Main Methods:

  • Case-control study design involving 290 CHD patients, 193 non-CHD controls, and 330 healthy volunteers.
  • Standardized coronary angiography was used for CHD diagnosis.
  • Analysis of APOB, LPA, and LIPA gene variants (rs562338, rs503662, rs7767084, rs2246942) and their association with CHD.

Main Results:

  • APOB gene variants rs503662 and rs562338 were rare in the Han Chinese population (minor allele frequency <1%).
  • LIPA gene variant rs2246942-GG was associated with increased CHD risk (P=0.04, OR=1.63).
  • LPA gene variant rs7767084-CC was a protective factor against CHD in females (P=0.04, OR=0.21).
  • A meta-analysis indicated rs7767084 is not associated with a high risk of CHD (P=0.83).

Conclusions:

  • The LIPA gene variant rs2246942-GG is a risk factor for CHD in the Han Chinese.
  • The LPA gene variant rs7767084-CC may be a protective factor against CHD in females.
  • Further research and meta-analysis are needed to clarify the role of rs7767084 in CHD risk.

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