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Published on: August 15, 2025
Central granular cell odontogenic tumor: a systematic review
Sachin C Sarode1, Gargi S Sarode, Kedar Vaidya
1Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Summary
Central granular cell odontogenic tumor (CGCOT) is a rare benign neoplasm. This systematic review analyzes its clinical, radiological, and histopathological features, confirming its non-aggressive behavior and recommending surgical removal.
Area of Science:
- Oral pathology
- Odontogenic neoplasms
- Tumor biology
Background:
- Central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm.
- It is not included in the 2005 WHO classification of odontogenic tumors.
- CGCOT typically affects middle-aged women, presenting as asymptomatic mandibular swelling.
Purpose of the Study:
- To conduct a systematic review of Central granular cell odontogenic tumor (CGCOT).
- To analyze clinical, radiological, histopathological, immunohistochemical, and treatment aspects of CGCOT.
- To consolidate existing knowledge on this rare odontogenic neoplasm.
Main Methods:
- Systematic literature search of PubMed, MEDLINE, and Scopus databases.
- Inclusion of papers published from 1950 to March 2013.
- Review of 26 articles (38 cases) from an initial 37 papers.
Main Results:
- CGCOT presents as a radiolucent lesion in the mandibular premolar-molar region.
- Histopathology reveals round to polygonal cells with granular cytoplasm and eccentrically placed nuclei.
- Immunohistochemistry and ultrastructural studies suggest a histiocytic origin for the granular cells.
Conclusions:
- Central granular cell odontogenic tumor (CGCOT) exhibits non-aggressive biological behavior.
- Enucleation or curettage for complete removal is the recommended treatment.
- Further research may clarify the precise origin and classification of CGCOT.