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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

Paroxetine hydrochloride.

David Germann1, George Ma, Feixue Han

  • 1Apotex Inc., Toronto, Ontario, Canada.

Profiles of Drug Substances, Excipients, and Related Methodology
|May 15, 2013
PubMed
Summary
This summary is machine-generated.

This review details paroxetine hydrochloride, a selective serotonin reuptake inhibitor (SSRI) used for various mental health conditions. It covers its properties, analysis, and pharmacological effects.

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Area of Science:

  • Pharmacology and Pharmaceutical Sciences
  • Analytical Chemistry

Background:

  • Paroxetine hydrochloride is a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI).
  • It is clinically prescribed for depression, anxiety disorders, OCD, panic disorder, PTSD, and social anxiety disorder.

Purpose of the Study:

  • To provide a comprehensive review of paroxetine hydrochloride.
  • To document its physicochemical properties, spectroscopic data, stability, preparation, and analytical methods.

Main Methods:

  • Literature review of existing studies on paroxetine hydrochloride.
  • Compilation of data on spectroscopic analysis (NMR, UV, FT-IR, MS, PXRD).
  • Summary of pharmacokinetic, metabolic, and pharmacological data.

Main Results:

  • Detailed physicochemical and spectroscopic characterization of paroxetine hydrochloride.
  • Established methods for preparation and chromatographic analysis in pharmaceutical and biological samples.
  • Overview of paroxetine's pharmacokinetics, metabolism, and effects.

Conclusions:

  • This review consolidates critical information on paroxetine hydrochloride, essential for researchers and clinicians.
  • It highlights the importance of analytical and pharmacological understanding for effective therapeutic use.