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Multifocal choroiditis without panuveitis: clinical characteristics and progression.

Adrian T Fung1, Samriti Pal, Nicolas A Yannuzzi

  • 1*Vitreous-Retina-Macula Consultants of New York, New York, New York; †LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Institute, New York, New York; ‡Division of Biostatistics and Epidemiology, Department of Public Health, Weill Cornell Medical College, New York, New York; §Department of Medicine, California Pacific Medical Center, San Francisco, California; ¶Department of Ophthalmology, Stanford University School of Medicine, Stanford, California; and **West Coast Retina Medical Group, San Francisco, California.

Retina (Philadelphia, Pa.)
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Multifocal choroiditis in women often presents without anterior uveitis or vitritis. While vision is generally preserved, some patients develop choroidal neovascularization over time.

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Area of Science:

  • Ophthalmology
  • Immunology

Background:

  • Multifocal choroiditis (MFC) is an inflammatory eye condition.
  • Some patients present with minimal or no anterior uveitis or vitritis.

Purpose of the Study:

  • To characterize the clinical features and disease progression in patients with MFC lesions but minimal or no anterior inflammation.
  • To understand the long-term outcomes and visual acuity in this specific patient subgroup.

Main Methods:

  • Retrospective, observational, single-center case series.
  • Analysis of clinical histories, ophthalmic examinations, and multimodal imaging.
  • Evaluation of 65 eyes from 41 patients diagnosed with MFC.

Main Results:

  • The study identified 41 patients (70.7% women), with a mean age of 38.4 years.
  • Bilateral involvement occurred in 51.2% of patients at presentation.
  • Over 60 months, 46.7% developed new lesions, and 32.6% developed choroidal neovascularization (CNV).
  • 60-month CNV event-free survival was 68.1%.

Conclusions:

  • MFC patients with minimal anterior inflammation are often young women.
  • Bilateral involvement at presentation is less common than in panuveitis forms.
  • A significant proportion may develop new lesions or CNV over time, necessitating monitoring.