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A ratiometric naphthalimide sensor for live cell imaging of copper(I)
Cristina Satriano1, Giuseppe Trusso Sfrazzetto, Maria Emanuela Amato
1Department of Chemical Sciences, University of Catania, viale Andrea Doria, 6, 95125 Catania, Italy.
Chemical Communications (Cambridge, England)
|May 16, 2013
Abstract:
A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu(+) was synthesised. Copper recognition properties in solution were evaluated using (1)H NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of the new sensor for the two-wavelength detection of intracellular monovalent copper in neuronal cells.