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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
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Published on: April 18, 2015

Classic models for dynamic contrast-enhanced MRI.

Steven P Sourbron1, David L Buckley

  • 1Division of Medical Physics, University of Leeds, Leeds, UK. s.sourbron@leeds.ac.uk

NMR in Biomedicine
|May 16, 2013
PubMed
Summary
This summary is machine-generated.

This review clarifies dynamic contrast-enhanced MRI (DCE-MRI) tracer-kinetic models. It explains the relationship between first and second-generation models and model-free methods for accurate physiological parameter interpretation.

Keywords:
DCE-MRIDSC-MRIdeconvolutionperfusionpermeabilitytracer-kinetic models

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Pharmacokinetics

Background:

  • Dynamic Contrast-Enhanced MRI (DCE-MRI) uses T1-weighted imaging after contrast agent injection.
  • Tracer-kinetic modeling interprets DCE-MRI data to reveal physiological tissue characteristics.
  • Brain applications include measuring cerebral blood flow (CBF), cerebral blood volume (CBV), and blood-brain barrier (BBB) permeability.

Purpose of the Study:

  • To clarify the relationships between first and second-generation DCE-MRI tracer-kinetic models.
  • To elucidate the connections between model-based and model-free deconvolution methods.
  • To provide a unified terminology for DCE-MRI parameters across different organs.

Main Methods:

  • Review of existing literature on DCE-MRI tracer-kinetic modeling.
  • Comparative analysis of first-generation, second-generation, and model-free methods.
  • Definition of generic terminology for DCE-MRI parameters.

Main Results:

  • First-generation models are established standards; second-generation models offer increased complexity.
  • Lack of clarity exists regarding the relationship between different model types and their interpretation.
  • A generic terminology facilitates understanding and application across various organs.

Conclusions:

  • Clearer understanding of DCE-MRI models is needed to reduce confusion in parameter interpretation.
  • Standardized terminology will enhance the applicability and comparability of DCE-MRI studies.
  • This review provides a framework for selecting and interpreting DCE-MRI models effectively.