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Updated: May 11, 2026

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Comparison of three-dimensional pseudo-continuous arterial spin labeling perfusion imaging with gradient-echo and
Alex M Wong1, Feng-Xian Yan, Ho-Ling Liu
1Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Keelung, Linkou Medical Center, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Purpose:
To compare the relative cerebral blood flow (CBF) obtained by pseudo-continuous arterial spin labeling sequence incorporated with volumetric fast spin-echo readout (3D-PCASL) with those by gradient-echo (GE) and spin-echo (SE) dynamic susceptibility contrast (DSC) MRI.
Materials And Methods:
Thirty patients with various neurological diseases participated in this study. In addition to 3D-PCASL, 15 patients received GE-DSC and the others received SE-DSC imaging on a 3 Tesla scanner. A cortical gray matter (GM) to white matter (WM) and a thalamus (TM) to WM CBF ratio were determined from each perfusion scan. In addition, histograms of relative CBF distributions were obtained from each method for comparison.
Results:
Significant correlations of CBF ratios were found between 3D-PCASL and the two DSC methods (P < 0.05). The 3D-PCASL resulted in GM/WM CBF ratios similar to SE-DSC but significantly smaller than GE-DSC (P = 2.3 × 10(-7) ). TM/WM CBF ratio obtained by 3D-PCASL was significantly smaller than those by GE- and SE-DSC (P = 4.1 × 10(-7) and 1.2 × 10(-6) , respectively). The histogram of relative CBF maps obtained from SE-DSC, after applied spatial smoothing, agreed well with that from 3D-PCASL.
Conclusion:
This study suggested that perfusion images obtained from 3D-PCASL exhibited significant correlations with DSC-MRI, with greater microvascular weighting like SE-DSC.
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