Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Standards of Care II

Standards of Care II

Nurses bear specific legal responsibilities under several federal statutes, including:

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...

Cis-regulatory Sequences

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

Cis-regulatory Sequences

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reproducibility of aortic valve calcification scoring with computed tomography - An interplatform analysis.

Journal of cardiovascular computed tomography·2019

Same author

Early Clinical Experience with Double Ring Implantation for Aortic and Mitral Valve Repair.

The Thoracic and cardiovascular surgeon·2018

Same author

The last frontier: transcatheter devices for percutaneous or minimally invasive treatment of chronic heart failure.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2017

Same author

Transcatheter mitral direct annuloplasty: state of the art.

Minerva cardioangiologica·2014

Same author

Interventional vs. surgical mitral valve therapy. Which technique for which patient?

Herz·2013

Same author

The pivotal role of echocardiography in the assessment of multivalvular heart disease.

Minerva cardioangiologica·2013

Search research articles

Related Experiment Video

Updated: May 11, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

MitraClip Registries: what have we learned recently.

¹Cardiothoracic Department, San Raffaele Hospital, Milan, Italy. francesco.maisano@hsr.it

Minerva Cardioangiologica

|May 18, 2013

Summary

MitraClip therapy offers a safe alternative for mitral regurgitation in high-risk patients, showing non-inferior efficacy compared to surgery in elderly individuals. Real-world data is crucial as its use expands beyond initial trial parameters.

More Related Videos

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

Related Experiment Videos

Last Updated: May 11, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

Area of Science:

Cardiology
Interventional Cardiology
Medical Devices

Background:

MitraClip therapy is an emerging treatment for primary and secondary mitral regurgitation.
It is particularly considered for high-risk patients unsuitable for traditional surgery.
Previous trials demonstrated safety and non-inferiority to surgery in specific elderly populations.

Purpose of the Study:

To evaluate the real-world experience and outcomes of MitraClip therapy.
To assess the use of MitraClip in patients outside the initial randomized trial criteria.
To gather preliminary data from ongoing registries on percutaneous mitral valve repair.

Main Methods:

Analysis of data from multiple registries collecting real-world evidence.
Observational studies focusing on patients treated with the MitraClip system.
Comparison of outcomes in a broader patient population than initially studied.

Main Results:

MitraClip therapy is being utilized in a wider patient demographic post-commercialization.
Registries are providing initial insights into the effectiveness and safety in diverse real-world settings.
Preliminary data suggests MitraClip is a viable option for patients with varying mitral regurgitation types.

Conclusions:

MitraClip therapy is expanding its application in managing mitral regurgitation.
Real-world data from registries is essential for understanding its broad clinical utility.
Further research is needed to fully characterize outcomes in diverse patient groups.