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Updated: May 11, 2026
08:53
Automated 90Sr Separation and Preconcentration in a Lab-on-Valve System at Ppq Level
Published on: June 6, 2018
Automatic and simple method for ⁹⁹Tc determination using a selective resin and liquid scintillation detection applied
Marina Villar1, Jessica Avivar, Laura Ferrer
1Radiopharmacy Service, Son Espases Hospital, Cra. Valldemossa 79, 07120 Palma de Mallorca, Spain.
Analytical Chemistry
|May 21, 2013
Summary
A new automatic Lab-on-valve system effectively monitors technetium-99 ((99)Tc) in patient urine. This method offers precise, rapid, and cost-effective analysis for environmental and medical safety.
Area of Science:
- Nuclear Chemistry
- Analytical Chemistry
- Environmental Science
Background:
- Technetium-99 ((99)Tc) is a radioactive isotope of concern due to its long half-life and mobility.
- Monitoring (99)Tc in patient urine is crucial following diagnostic procedures using its parent isotope, Technetium-99m ((99m)Tc).
Purpose of the Study:
- To develop an automated Lab-on-valve (LOV) system for the separation and preconcentration of (99)Tc from urine samples.
- To establish a precise, rapid, and cost-effective method for monitoring low levels of (99)Tc in clinical settings.
Main Methods:
- Utilized a Lab-on-valve (LOV) system integrated with TEVA resin for selective retention of pertechnetate ions.
- Employed liquid scintillation counting (LSC) for the detection of eluted (99)Tc.
- Optimized the system for preconcentrating 100 mL of urine sample.
Main Results:
- Achieved high recoveries for (99)Tc in urine samples, ranging from 94-111%.
- Established a minimum detectable activity (MDA) of 0.1 Bq (or 1 Bq L(-1) concentration) for the developed method.
- Demonstrated excellent reproducibility (RSD 2%, n=5) and a high extraction frequency (up to 12 h(-1)).
Conclusions:
- The automated LOV system provides an inexpensive, precise, and fast tool for monitoring (99)Tc in urine.
- The method's efficiency and low resin requirement make it suitable for routine clinical and environmental analysis.
- This technology aids in managing potential health risks associated with (99)Tc exposure.
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