Related Experiment Video
Updated: May 11, 2026
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Anterior segment optical coherence tomography: assisted topographic corneal epithelial thickness distribution imaging
A John Kanellopoulos1, George Asimellis
1Laservision.gr Eye Institute, Athens, Greece ; NYU Medical School, New York, N.Y., USA.
Purpose:
To evaluate safety, efficacy and ease of measurement of epithelial thickness in a keratoconic patient based on anterior segment optical coherence tomography (AS-OCT).
Methods:
A 25-year-old male patient, previously diagnosed with keratoconus, with highly asymmetric manifestation among the two eyes, was subjected to AS-OCT corneal epithelial imaging. We investigated epithelial thickness and epithelial topographic thickness distribution.
Results:
Mean epithelial thickness was 51.97 ± 0.70 for the less affected right eye (OD), and 55.65 ± 1.22 for the more affected left eye (OS). Topographic epithelial thickness variability for the OD was 1.53 ± 0.21 μm, while for the OS it was 9.80 ± 0.41 μm.
Conclusions:
This case further supports our previous findings with high-frequency ultrasound measurements of the increase in overall epithelial thickness in keratoconic eyes in comparison with normal eyes. AS-OCT further offers ease of use and possibly higher predictability of measurement. This case report, based on AS-OCT imaging, verifies increased overall epithelial thickness in keratoconic eyes, as introduced by a previous study [Kanellopoulos et al.: Clin Ophthalmol 2012;6:789-800], based on high-frequency scanning ultrasound biomicroscopy imaging.
