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Updated: May 11, 2026
In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
Published on: February 3, 2018
NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear
Louise E Wedlock1, Matt R Kilburn, Rong Liu
1Institute for Glycomics, Griffith University, Gold Coast Campus, QLD 4222, Australia.
Abstract:
Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.
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