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Circular dichroism studies on intermolecular interactions of amphotericin B in ionic liquid-rich environments
Laramie P Jameson1, Sergei V Dzyuba
1Department of Chemistry, Texas Christian University, Fort Worth, TX 76129, USA.
Abstract:
Aggregation of amphotericin B (AmB) in an ionic liquid-rich environment was investigated using circular dichroism (CD) spectroscopy. It was found that nature of the ionic liquids' anion had a strong impact not only on the aggregation of AmB, but more importantly on the nature of AmB aggregates, as observed in the asymmetry of the exciton couplet of the aggregate in CD spectra. Unique CD signals for AmB aggregates were observed in three different 1-butyl-3-methylimidazolium ionic liquid solutions: [C4 -mim]Br favored the formation of AmB aggregates that were similar to those found in water, whereas [C4 -mim]BF4 and [C4 -mim]NO3 produced AmB aggregates that were different from each other and those found in water. The obtained results suggest that the designer solvent ability of ionic liquids could be expanded to address numerous intermolecular processes.
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