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Updated: May 11, 2026
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Comment on: EGFR mutational status in Brazilian patients with penile carcinoma
Abstract:
The authors describe the results on EGFR molecular alterations of 29 Brazilian patients with penile carcinoma (PC). DNA extracted from frozen tumor tissue of all patients was submitted to direct sequencing of the four exons (18 - 21) responsible for the EGFR tyrosine-kinase activity. Corroborating the data by Di Lorenzo et al. published in Expert Opin Ther Targets, none of the sequenced tumor samples showed relevant alterations in the four studied exons of the EGFR gene.
Insights
Researchers investigated EGFR gene alterations in Brazilian penile carcinoma (PC) patients. Direct sequencing of key exons revealed no significant EGFR mutations, suggesting this pathway is not a primary driver in this cohort.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Penile carcinoma (PC) is a rare cancer with limited treatment options.
- Epidermal Growth Factor Receptor (EGFR) is a key target in various cancers.
- Understanding molecular alterations in PC is crucial for developing targeted therapies.