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Updated: May 11, 2026

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO2 Source
Published on: August 17, 2018
Modernized low pressure carbonylation methods in batch and flow employing common acids as a CO source
Célia Brancour1, Takahide Fukuyama, Yu Mukai
1Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Abstract:
Carbonylation reactions, such as Heck, Sonogashira, and radical carbonylations, were successfully carried out in a "two-chamber reactor" where carbon monoxide was produced ex situ by the Morgan reaction (dehydration of formic acid by sulfuric acid). By a subsequent application in a microflow system using a "tube-in-tube" reactor where gas-permeable Teflon AF2400 was used as the inner tube, it is demonstrated that formic acid/sulfuric acid can be employed concomitantly with an amine base such as triethylamine in the Heck aminocarbonylation of aryl iodide.
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