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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
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The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
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Published on: September 17, 2016

Ribonucleoprotein complexes that control circadian clocks.

Dongni Wang1, Xiaodi Liang, Xianyun Chen

  • 1Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. guojinhu@mail.sysu.edu.cn.

International Journal of Molecular Sciences
|May 24, 2013
PubMed
Summary
This summary is machine-generated.

Circadian clocks regulate daily physiology. Ribonucleoprotein complexes (RNPs) are crucial for post-transcriptional control of these clocks, impacting health when misaligned.

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Area of Science:

  • Molecular Biology
  • Chronobiology
  • Genetics

Background:

  • Circadian clocks are endogenous timekeepers essential for physiological and behavioral adaptation.
  • Disruptions in circadian timing are linked to various health impairments.
  • Post-transcriptional and translational regulation are key to circadian clock function.

Purpose of the Study:

  • To review the current understanding of ribonucleoprotein complexes (RNPs) in circadian clock regulation.
  • To highlight the role of RNA-binding proteins (RBPs) and RNPs in post-transcriptional control of circadian clocks.

Main Methods:

  • Literature review of studies on circadian clocks and RNP involvement.
  • Analysis of research implicating RBPs and RNPs in post-transcriptional modification of clock proteins.
  • Synthesis of findings across different model organisms.

Main Results:

  • RNPs play a significant role in the post-transcriptional regulation of circadian clocks.
  • Specific RBPs and their associated RNPs modify circadian clock proteins.
  • Evidence supports RNP involvement in circadian clock mechanisms across diverse species.

Conclusions:

  • RNPs are critical regulators of circadian clock function at the post-transcriptional level.
  • Further research into RNP complexes offers insights into circadian biology and potential therapeutic targets.
  • Understanding RNP roles is vital for addressing health issues related to circadian misalignment.