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Relationship between bone mineral density, weight, and estrogen levels in pre and postmenopausal women
Morcov Corina1, Carmen Vulpoi, D Brănişteanu
1University of Medicine and Pharmacy Grigore T Popa Iasi, Faculty of Medicine.
Unlabelled:
Bone loss in postmenopausal women is mainly due to estrogen deficiency affecting the balance between osteoclast resorption and bone formation controlled by osteoblasts.
Aim:
To determine the relationship between bone mineral density (BMD) in pre and postmenopausal Caucasian women, and estrogen levels.
Material And Methods:
Cross-sectional study including six groups of 8 to 15 pre- and postmenopausal healthy volunteers with different weights, body mass index (BMI) (normal or underweight < 25 kg/m2, overweight 25-30 kg/m2, and obese > 30 kg/m2), not exposed to antiosteoporotic therapy. Lumbar bone mineral density (BMD) and body composition (BC) were evaluated by dual X ray absorptiometry (DXA, Hologic), while serum estradiol and estrone were measured by ELISA.
Results:
BMD in postmenopausal women is lower than in premenopausal women irrespective of body weight (p<0.05). Estradiol and estrone are positively correlate with bone mass in premenopausal women, but not in postmenopausal women (R2 0.3209, R2 0.2579, respectively).
Conclusions:
It is very important to identify the risk factors for osteoporosis, especially in postmenopausal women, as we will show that aromatization of androgens into estrogens in adipose tissue appears not to have a significant role in postmenopausal women bone protection. Key-
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