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Updated: May 11, 2026

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
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Published on: February 12, 2018

Reproductive aging in men.

Shehzad Basaria1

  • 1Section of Men's Health, Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. sbasaria@partners.org

Endocrinology and Metabolism Clinics of North America
|May 25, 2013
PubMed
Summary
This summary is machine-generated.

Testosterone levels naturally decline in aging men due to testicular changes. Addressing comorbidities like obesity may help maintain healthy androgen levels, rather than solely focusing on testosterone therapy for late-onset hypogonadism.

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Area of Science:

  • Endocrinology
  • Andrology
  • Aging Research

Background:

  • Aging men experience decreased serum testosterone linked to Leydig cell attrition and slowed GnRH pulse generation.
  • Late-onset hypogonadism (LOH) is often considered in older men, but frequently misdiagnosed, with organic hypogonadism.
  • Testosterone levels may serve as a biomarker of overall health in aging males.

Purpose of the Study:

  • To differentiate between late-onset hypogonadism (LOH) and organic hypogonadism in aging men.
  • To investigate the role of comorbidities and obesity in age-related androgen decline.
  • To explore the potential of managing comorbidities to mitigate declining testosterone levels.

Main Methods:

  • Review of recent data utilizing syndromic definitions for LOH diagnosis.
  • Analysis of factors contributing to LOH in men aged 40-80.
  • Correlation of comorbidities and obesity with serum testosterone levels.

Main Results:

  • Only 2% of men aged 40-80 meet the syndromic definition of LOH.
  • Comorbidities and obesity are significant contributors to LOH.
  • Testosterone levels appear to be a biomarker for health status.

Conclusions:

  • Late-onset hypogonadism (LOH) is less prevalent than often assumed.
  • Managing comorbidities and obesity is crucial and may help attenuate age-related testosterone decline.
  • Testosterone therapy should be considered carefully, with a focus on underlying health.