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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Updated: May 11, 2026

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10:46

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Published on: December 9, 2015

Vitamin D and aging.

J Christopher Gallagher1

  • 1Endocrine Department, Creighton University Medical School, Omaha, NE 68131, USA. jcg@creighton.edu

Endocrinology and Metabolism Clinics of North America
|May 25, 2013
PubMed
Summary
This summary is machine-generated.

Elderly individuals need more vitamin D and calcium due to aging. Increasing intake to 800 IU vitamin D and 1000 mg calcium daily can reduce fractures by 30%.

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Bone Health

Background:

  • Aging impacts vitamin D metabolism, increasing requirements in older adults.
  • Calcium absorption decreases with age, necessitating higher dietary calcium intake.
  • Dietary calcium sources, like dairy and fortified foods, may be preferable to supplements.

Purpose of the Study:

  • To determine optimal vitamin D and calcium intake for improving nutrition in the elderly.
  • To assess the efficacy of increased vitamin D and calcium intake in reducing fractures among institutionalized individuals.

Main Methods:

  • Review of evidence on age-related changes in vitamin D and calcium metabolism.
  • Analysis of the impact of increased dietary intake of vitamin D and calcium.
  • Evaluation of fracture reduction rates in institutionalized populations following nutritional interventions.

Main Results:

  • Recommended daily intake for the elderly: 800 IU of vitamin D and 1000 mg of total calcium.
  • This nutritional strategy is simple and cost-effective.
  • A 30% reduction in fractures was observed in institutionalized individuals.

Conclusions:

  • Optimizing vitamin D and calcium intake is crucial for elderly bone health.
  • A combined intake of 800 IU vitamin D and 1000 mg calcium daily is an effective strategy.
  • This approach significantly reduces fracture risk in institutionalized elderly populations.