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Updated: May 11, 2026

Cochlear Implantation in the Guinea Pig
Published on: June 15, 2018
Nitric oxide levels in cochlear fluids of guinea pig
Fernando Kaoru Yonamine1, Ektor Tsuneo Onishi, Margareth Gori Mouro
1Department of Otorhinolaryngology, Head and Neck Surgery, Federal University of Sao Paulo, Brazil. ferky@uol.com.br
Purpose:
To describe a technique to obtain guinea pigs cochlear fluids and measure nitric oxide (NO) concentration.
Methods:
Six guinea pigs were used and sacrificed. The cochlear fluids collected for measurement of NO, performed by chemiluminescence (NOA 280).
Results:
Through the chemiluminescence was possible to analyze the concentration of NO in cochlear fluids obtained. Average levels of nitric oxide from guinea pigs was 12.55 µM.
Conclusion:
It is possible to obtain nitric oxide cochlear fluids, with this technique and nitric oxide concentration measure by chemiluminescence, a quantitative and more precise method.
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