CGRP-alpha application: a potential treatment to improve osseoperception of endosseous dental implants

Dental implants have been used to restore missing teeth for several decades. However, the capacity of implants to feel the mechanical stimuli and transmit neural signals remains lower than that of natural teeth. The poor osseoperception of dental implants is due to the absence of periodontal ligaments and Ruffini-like endings as well as the secondary injury during the implant surgery and then the insufficient regeneration of damaged peripheral nerve fibers around the implants. It is a hot topic to improve the quantity and density of peripheral nerve fibers or mechanoreceptors around endosseous dental implants. Calcitonin gene-related peptide-alpha (αCGRP), a neuropeptide widely distributed throughout the central and peripheral nervous systems, is found to be upregulated in regenerating axons within injury zones and be capable of promoting local Schwann cells proliferation, which is critical for partnering during peripheral nerve regeneration. Moreover, researches show that αCGRP is a potent vasodilator and a physiologic activator of bone formation. Thus, we hypothesize that local application of αCGRP may promote peripheral nerve fibers regeneration during the bone healing progress after dental implant surgery, thus improve the osseoperception of dental implants.