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Methodological aspects of flow-volume studies in infants.
D J Turner1, S E Morgan, L I Landau
1Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Australia.
Pediatric Pulmonology
|January 1, 1990
Summary
This study on infant respiratory mechanics found that chloral hydrate slightly reduced tidal volume but did not affect other flow-volume measurements. Nebulized saline and salbutamol also showed no significant impact on infant respiratory parameters.
Area of Science:
- Pediatric Pulmonology
- Respiratory Physiology
Background:
- New techniques for infant respiratory mechanics assessment are valuable but raise methodological concerns.
- Potential effects of chloral hydrate on upper airway caliber and nebulized solutions on physiological changes require investigation.
Purpose of the Study:
- To investigate the effects of chloral hydrate and nebulized solutions on infant respiratory mechanics.
- To validate assumptions underlying infant flow-volume techniques.
Main Methods:
- Assessed thoracic gas volume and respiratory mechanics using passive and forced expiratory flow-volume techniques in normal infants.
- Measured respiratory function before and after chloral hydrate administration, nebulized saline, and nebulized salbutamol.
Main Results:
- Chloral hydrate administration resulted in a fall in tidal volume but no significant changes in other respiratory parameters.
- Nebulized saline and salbutamol did not significantly alter any measured respiratory parameters.
Conclusions:
- Findings support basic assumptions of infant flow-volume techniques.
- Provides background data for future studies on infant respiratory function assessment.