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[(DPEPhos)(bcp)Cu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Pd(II)-catalyzed aminotetrazole-directed ortho-selective halogenation of arenes
Pradeep Sadhu1, Santhosh Kumar Alla, Tharmalingam Punniyamurthy
1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Abstract:
A Pd(II)-catalyzed ortho-selective halogenation of N-aryl ring of N,1-diaryl-1H-tetrazol-5-amine has been described employing N-halosuccinimide as a halogen source via C-H bond activation. The present work features 5-aminotetrazole, as a directing group, for the chemo- and regioselective C-H halogenation of arenes. The kinetic isotope study (kH/kD = 2.9) suggests that the cleavage of the C-H bond takes place in the rate-determining step. The scope and mechanism of the protocol have been demonstrated.
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