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Updated: May 11, 2026

Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies
Published on: April 12, 2022
Porous aerosil loading probucol using supercritical carbon dioxide: preparation, in vitro and in vivo characteristics
Chunxia Chu1, Muhua Liu, Dongmei Wang
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University , No. 103, Wenhua Road, Shenyang 110016 , PR China.
Abstract:
The aim of this study was to enhance the dissolution rate and oral bioavailability of probucol. Probucol was adsorbed onto aerosils via supercritical carbon dioxide (ScCO2) and the physicochemistry properties of probucol-aerosil powder were evaluated by differential scanning calorimetry, X-ray diffraction, infrared spectroscopy and scanning electron microscopy. Tablets of the probucol-aerosil powder were prepared by direct compression method. In the dissolution test, the probucol-aerosil tablets showed a significant enhanced dissolution rate compared with commercial tablets. Bioavailability study was carried out in beagle dogs. Probucol-aerosil tablets exhibited higher AUC and Cmax than commercial tablets. The improved dissolution and bioavailability of probucol-aerosil tablets were attributed to the amorphous state and good dispersion of probucol. It is a feasible method to enhance the oral bioavailability by adsorbing probucol onto aerosils via ScCO2.
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