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[Phenolic constituents from Lysimachia patungensis]
Peng Zeng1, Yong Zhang, Chen Pan
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|June 4, 2013
Summary
This study isolated twelve phenolic compounds from Lysimachia patungensis Hand.-Mazz., including one new compound and three compounds new to the Lysimachia genus. These findings expand the known chemical diversity of this plant species.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Medicinal Plant Research
Background:
- Lysimachia patungensis Hand.-Mazz. is a plant species with potential medicinal properties.
- Understanding its chemical constituents is crucial for exploring its pharmacological applications.
- Previous phytochemical investigations on this specific species are limited.
Purpose of the Study:
- To isolate and identify the chemical constituents present in the whole plant of Lysimachia patungensis Hand.-Mazz.
- To characterize novel compounds and those previously unrecorded in the Lysimachia genus.
- To contribute to the phytochemical knowledge base of Lysimachia species.
Main Methods:
- Extraction of the whole plant using 95% ethanol.
- Separation and purification employing silica gel column chromatography, reverse-phase ODS column chromatography, MCI, and Sephadex LH-20.
- Structure elucidation utilizing chemical methods, Nuclear Magnetic Resonance (NMR) spectroscopy, and Electrospray Ionization Mass Spectrometry (ESI-MS).
Main Results:
- Twelve phenolic compounds were successfully isolated and identified.
- Compound 1, quercetin-3, 3'-di- O-alpha-L-rhamnoside, is a novel compound.
- Compounds 5 (2-hydroxynaringenin-4'-O-glucopyranoside), 11 (2, 4, 6-trihydroxy acetophenone-2-O-glucopyranoside), and 12 (vaccihein A) were isolated from the Lysimachia genus for the first time.
- Compounds 2-4, 6-10 were isolated from Lysimachia patungensis Hand.-Mazz. for the first time.
Conclusions:
- The phytochemical investigation of Lysimachia patungensis Hand.-Mazz. yielded twelve phenolic compounds.
- The discovery of a new compound and compounds new to the genus highlights the phytochemical richness of this species.
- These identified compounds provide a foundation for further research into the biological activities and potential therapeutic applications of Lysimachia patungensis Hand.-Mazz.
