Related Experiment Videos
Local glucose utilization changes caused by subarachnoid contrast media in the rabbit
S E Ekholm1, T W Morris, L Prentice
1Department of Radiology, University of Rochester Medical Center, New York.
Acta Radiologica (Stockholm, Sweden : 1987)
|March 1, 1990
Summary
Iohexol showed fewer negative effects on brain glucose metabolism compared to metrizamide and iodixanol contrast agents after subarachnoid injection in rabbits. This suggests iohexol may be safer for brain tissue glucose metabolism.
Area of Science:
- Neuroscience
- Radiology
- Biochemistry
Background:
- Subarachnoid injections of contrast media are used in neuroradiology.
- Understanding the impact of contrast media on brain metabolism is crucial for patient safety.
Purpose of the Study:
- To investigate the effects of metrizamide, iohexol, and iodixanol on brain glucose metabolism in rabbits following subarachnoid injection.
- To compare the metabolic effects of different contrast agents on cortical brain tissue.
Main Methods:
- In vivo study in 18 rabbits.
- Subarachnoid injections of metrizamide, iohexol, iodixanol, and control solutions.
- Measurement of 14C-labeled deoxyglucose uptake in brain tissue using autoradiography after six-hour exposures.
Main Results:
- Metrizamide and iodixanol significantly decreased deoxyglucose uptake in outer cortical areas (p < 0.05).
- Iohexol and control solutions did not produce significant changes in deoxyglucose uptake.
- Contrast medium concentration correlated with decreased glucose metabolism in affected cortical areas.
Conclusions:
- Iohexol demonstrates less impact on brain glucose metabolism compared to metrizamide and iodixanol.
- The non-ionic dimer iodixanol, despite its formulation, showed significant effects on glucose metabolism.
- Iohexol appears to be a potentially safer contrast agent regarding brain tissue glucose metabolism.