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Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study

Turan Erdoğan1, Sinan Altan Kocaman, Mustafa Çetin

  • 1Departments of Cardiology, Faculty of Medicine, Rize University, Rize-Turkey. sinanaltan@gmail.com.

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|June 4, 2013
PubMed

Insights

YKL-40 levels are significantly higher in patients with coronary artery ectasia (CAE) compared to normal arteries. This inflammatory marker, YKL-40, was identified as the sole determinant of CAE, suggesting its potential role in the condition.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Coronary artery ectasia (CAE) has an unclear cause, potentially linked to intense inflammation.
  • YKL-40 is an inflammatory biomarker secreted by macrophages in atherosclerotic plaques.

Purpose of the Study:

  • To investigate YKL-40 and C-reactive protein (CRP) levels in patients with isolated CAE.
  • Compare these levels against patients with normal coronary arteries (NCA) and coronary artery disease (CAD).

Main Methods:

  • Observational, cross-sectional study design.
  • Included 49 patients with isolated CAE, 30 with NCA, and 30 with CAD.
  • Analyzed YKL-40 and CRP levels using univariate and multiple logistic regression.

Main Results:

  • Serum YKL-40 levels were significantly higher in CAE (144±68 μg/L) and CAD (180±117 μg/L) groups compared to the NCA group (110±53 μg/L).
  • C-reactive protein (CRP) levels did not differ significantly among the groups.
  • Logistic regression identified YKL-40 level as the sole determinant of CAE (OR: 1.010, p=0.027).

Conclusions:

  • Patients with isolated CAE exhibit significantly elevated YKL-40 levels compared to those with NCA.
  • YKL-40 is established as the independent determinant of CAE.
  • Further research is warranted to elucidate the causative role of YKL-40 in isolated CAE.
Abstract

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