[Treatment of persistent corneal epithelial disorders with human plasma fibronectin eyedrops]

Fibronectin (FN), a glycoprotein present in plasma and the extracellular matrix, is responsible for cellular adhesion. 14 eyes with persistent corneal epithelial defects of various etiology were treated with FN to evaluate its effect on corneal epithelial wound healing. Human plasma fibronectin eyedrops (200 micrograms/ml) were instilled 5 times in addition to gentamycin eyedrops 2 times a day. The eyes healed completely in an average 20.4 days, with no recurrence in follow-ups of 1 to 3 months.