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Photo-oxidative damage to lenticular GAPDH and its relationship to aldehyde metabolism

J Jedziniak1

  • 1Harvard Medical School, Massachusetts Eye and Ear Infirmary, Howe Laboratory of Ophthalmology, Boston 02114.

Experimental Eye Research
|June 1, 1990
PubMed

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Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...