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Updated: May 10, 2026

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
[From cannabis to selective CB2R agonists: molecules with numerous therapeutical virtues]
Natascha Leleu-Chavain1, Christophe Biot, Philippe Chavatte
1Institut de chimie pharmaceutique Albert Lespagnol, université Lille Nord, EA 4481, IFR114, 3, rue du Pr Laguesse, BP 83, 59006 Lille, France.
Abstract:
Originally used in Asia for the treatment of pain, spasms, nausea and insomnia, marijuana is the most consumed psychotropic drug worldwide. The interest of medical cannabis has been reconsidered recently, leading to many scientific researches and commercialization of these drugs. Natural and synthetic cannabinoids display beneficial antiemetic, anti-inflammatory and analgesic effects in numerous diseases, however accompanied with undesirable effects due to the CB1 receptor. Present researches focus on the design of therapeutical molecules targeting the CB2 receptors, and thus avoiding central side effects and therefore psychotropic effects caused by the CB1 receptor.
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