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Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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[Metabolic abnormalities in young offsprings of parents with essential hypertension]

Miguel H Vicco1, Luz Rodeles, Lucía I César

  • 1Servicio de Clínica Médica, Hospital J. B. Iturraspe. mvicco@santafe-conicet.gov.ar

Medicina
|June 5, 2013
PubMed

Insights

Healthy young adults with hypertensive parents showed no significant differences in insulin, cortisol, or microalbuminuria levels. This study found no link between parental hypertension history and these cardiovascular risk markers in offspring.

Area of Science:

  • Endocrinology
  • Cardiovascular Health
  • Nephrology

Background:

  • Hypertension in offspring is linked to hyperinsulinemia, elevated cortisol, and renal damage.
  • Microalbuminuria is a marker of endothelial dysfunction and increased cardiovascular risk.

Purpose of the Study:

  • To investigate the association between insulin levels, serum cortisol, and microalbuminuria in healthy young adults with a parental history of hypertension.
  • To explore the relationship of these markers with increased cardiovascular risk.

Main Methods:

  • Cross-sectional correlational study in Santa Fe, Argentina.
  • 145 healthy individuals aged over 18 years were divided into a study group (hypertensive parents) and a control group.
  • Fasting serum insulin, serum cortisol, and first morning urine microalbuminuria were measured.

Main Results:

  • No significant differences were found in serum insulin, cortisol, or microalbuminuria between the study and control groups.
  • Prevalence of insulin resistance was 4.8%, microalbuminuria 13.8%, and hypercortisolemia 52%.
  • No correlation was identified between parental hypertension history and insulin, cortisol, or microalbuminuria levels.

Conclusions:

  • A parental history of hypertension was not associated with impaired insulin or cortisol homeostasis in healthy young offspring.
  • The study did not find a link between parental hypertension and early markers of cardiovascular risk in this cohort.

Keywords:
heredity and hypertensionhypertensionmicroalbuminuriaserum cortisol

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