Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Pulmonary Circulation01:19

Overview of Pulmonary Circulation

The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Anatomy of the Circulatory System02:03

Anatomy of the Circulatory System

The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
Respiration and Gaseous Exchange01:20

Respiration and Gaseous Exchange

The intricate interplay between the cardiovascular and respiratory systems is crucial for efficiently transporting respiratory gases throughout the body. Let us explore the cardiovascular system's multifaceted functions, emphasizing its pivotal role in gas exchange.
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves the...
External and Internal Respiration01:24

External and Internal Respiration

External respiration occurs in the lungs, and it is the first step in the journey of oxygen inside the body. When we inhale, oxygen enters our lungs and diffuses across the thin alveolar membrane. The alveoli are tiny, air-filled sacs that provide a vast surface area for gas exchange. Oxygen in the alveoli has a higher partial pressure (105 mmHg) than in the adjacent pulmonary capillaries (40 mmHg), establishing a pressure gradient. As a result, oxygen molecules move from the alveoli into the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One-year lung function change and variability post allogeneic hematopoietic stem cell transplantation.

Respiratory medicineยท2026
Same author

Potential pulmonary toxic effects of Martian dust simulant.

iScienceยท2025
Same author

The Alveolar Gas Monitor: An Alternative to Pulse Oximetry for the Noninvasive Assessment of Impaired Gas Exchange in Patients at Risk of Respiratory Deterioration.

Journal of clinical medicineยท2025
Same author

Emerging respiratory challenges in space and long-duration missions.

Respiratory medicine and researchยท2025
Same author

Advances in gas-exchange physiology and pathophysiology.

ERS monograph..ยท2025
Same author

Quantitative assessment of lung opacities from CT of pulmonary artery imaging data in COVID-19 patients: artificial intelligence versus radiologist.

BJR openยท2025
Same journal

SLIT-ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction.

Comprehensive Physiologyยท2026
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiologyยท2026
Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiologyยท2026
Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiologyยท2026
Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiologyยท2026
Same journal

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.

Comprehensive Physiologyยท2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

Pulmonary circulation in extreme environments.

G Kim Prisk1

  • 1Departments of Medicine and Radiology, University of California, San Diego, USA. kprisk@ucsd.edu

Comprehensive Physiology
|June 6, 2013
PubMed
Summary
This summary is machine-generated.

Altered gravity and ambient pressure significantly impact the pulmonary circulation, affecting gas exchange and blood flow. Understanding these effects is crucial for physiological adaptation in diverse environments like aviation, spaceflight, and diving.

More Related Videos

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
07:09

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Published on: February 20, 2017

Related Experiment Videos

Last Updated: May 10, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
07:09

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Published on: February 20, 2017

Area of Science:

  • Physiology
  • Cardiovascular Science
  • Environmental Medicine

Background:

  • The pulmonary circulation's thin-walled capillaries are vulnerable to pressure and gravity changes.
  • Lung compliance makes it susceptible to deformation, impacting blood flow distribution.

Purpose of the Study:

  • To review the effects of altered gravity and ambient pressure on the pulmonary circulation.
  • To highlight physiological challenges in aviation, spaceflight, and diving.

Main Methods:

  • Review of existing literature on pulmonary circulation under varying gravitational and pressure conditions.
  • Analysis of physiological responses to environmental extremes.

Main Results:

  • Ambient pressure changes directly affect pulmonary capillaries and blood flow.
  • Gravitational forces alter lung mechanics and hydrostatic pressure, influencing pulmonary blood flow.

Conclusions:

  • Pulmonary circulation is sensitive to environmental pressure and gravity.
  • Adaptation to extreme environments requires understanding these physiological impacts.