Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Pulmonary Ventilation: Inhalation01:24

Pulmonary Ventilation: Inhalation

Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mannose-6-phosphate attenuates acute lung injury by competitive release of acid sphingomyelinase from the mannose-6-phosphate receptor in endothelial caveolae.

The European respiratory journal·2025
Same author

Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca<sup>2+</sup>-sensitisation.

Respiratory research·2022
Same author

Stimulation of the EP<sub>3</sub> receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells.

The European respiratory journal·2022
Same author

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.

American journal of respiratory cell and molecular biology·2022
Same author

Reference Gene Selection for Gene Expression Analyses in Mouse Models of Acute Lung Injury.

International journal of molecular sciences·2021
Same author

Reliability of short-term measurements of heart rate variability: Findings from a longitudinal study.

Biological psychology·2020
Same journal

The Evolution of Taste: Genetic, Dietary, and Cultural Pathways in Human Taste Perception.

Comprehensive Physiology·2026
Same journal

SLIT-ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction.

Comprehensive Physiology·2026
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiology·2026
Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiology·2026
Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiology·2026
Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiology·2026
See all related articles

Related Experiment Video

Updated: May 10, 2026

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
07:55

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Published on: May 5, 2011

Ventilation-induced lung injury.

Ulrike Uhlig1, Stefan Uhlig

  • 1Department of Pharmacology & Toxicology, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Comprehensive Physiology
|June 6, 2013
PubMed
Summary
This summary is machine-generated.

Mechanical ventilation (MV) can harm lungs by applying excessive forces, leading to inflammation and injury. Blocking mechanotransduction or inflammation pathways may prevent ventilator-induced lung injury (VILI).

More Related Videos

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Intravital Widefield Fluorescence Microscopy of Pulmonary Microcirculation in Experimental Acute Lung Injury Using a Vacuum-Stabilized Imaging System
09:28

Intravital Widefield Fluorescence Microscopy of Pulmonary Microcirculation in Experimental Acute Lung Injury Using a Vacuum-Stabilized Imaging System

Published on: April 6, 2022

Related Experiment Videos

Last Updated: May 10, 2026

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
07:55

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Published on: May 5, 2011

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Intravital Widefield Fluorescence Microscopy of Pulmonary Microcirculation in Experimental Acute Lung Injury Using a Vacuum-Stabilized Imaging System
09:28

Intravital Widefield Fluorescence Microscopy of Pulmonary Microcirculation in Experimental Acute Lung Injury Using a Vacuum-Stabilized Imaging System

Published on: April 6, 2022

Area of Science:

  • Pulmonary Medicine
  • Biomedical Engineering
  • Cellular Biology

Background:

  • Mechanical ventilation (MV) applies external forces to the lungs, potentially causing significant pathophysiological changes.
  • In patients with acute lung injury (ALI), MV can exacerbate lung damage due to inhomogeneous injury and high ventilation pressures.
  • Lung cells possess mechanotransduction pathways that activate inflammation and repair in response to mechanical stress.

Purpose of the Study:

  • To discuss the mechanical forces generated by MV and their potential to induce lung injury.
  • To review the role of mechanotransduction in mediating inflammation and lung damage.
  • To explore preventive strategies for ventilator-induced lung injury (VILI) by targeting mechanotransduction and inflammation.

Main Methods:

  • Review of existing literature on mechanical ventilation, lung injury, mechanotransduction, and inflammation.
  • Discussion of the pathophysiological mechanisms linking MV forces to cellular responses.
  • Analysis of studies investigating interventions to prevent VILI.

Main Results:

  • MV forces can cause direct mechanical injury and trigger inflammatory responses in the lungs.
  • Mechanotransduction pathways translate mechanical stress into cellular signals, promoting inflammation.
  • Studies suggest that inhibiting specific mechanotransduction or inflammation pathways can prevent VILI.

Conclusions:

  • MV, especially in ALI patients, poses a risk of mechanical and inflammatory lung injury.
  • Understanding mechanotransduction is crucial for comprehending how MV leads to inflammation.
  • Targeting mechanotransduction and inflammation pathways offers promising therapeutic strategies for preventing VILI.